Fabio Ghiotto received a M.Sc. degree in Biology at the University of Milan in 1989, a Ph.D. in Genetics at the University of Pavia in 1994 and a Ph.D. in Immunology in 2001 at the University of Genoa. After his M.Sc. he worked first in the Regional Center of Human Genetics, Ospedali Galliera, Genova, and then at the Giannina Gaslini Institute, Genova, with Dr. Vito Pistoia, where he worked on autoimmunity and tumors of the immunological system until 1996. In March 1996 he moved to the Rheumathology and Allergology-Clinical Immunology Division, Department of Medicine, North Shore University Hospital-NYU School of Medicine, Manhasset, New York, USA, led by Dr. Nicholas Chiorazzi, where he focused on Chronic Lymphocytic Leukemia (CLL). In late 1997 he moved back to Genoa to the laboratory of Prof. Carlo Enrico Grossi at the Human Anatomy Section, Department of Experimental Medicine, University of Genoa, where he worked, and still currently does, on the biology of CLL and, more recently, on the functional characterization of the SH3BGR protein family.




Selected papers


Occhino M*, Ghiotto F*, Soro S, Mortarino M, Bosi S, Maffei M, Bruno S, Nardini M, Figini M, Tramontano A, Ciccone E. Dissecting the structural determinants of the interaction between the HCMV UL18 protein and the CD85j immune receptor. J Immunol 15;180(2): 957-68, 2008. *Gli autori hanno contribuito in eguale misura al lavoro.

Maffei M*, Ghiotto F,* Occhino M, Bono M, De Santanna A, Battini L, Gusella GL, Fais F, Bruno S, Ciccone E. The human cytomegalovirus regulates surface expression of the viral protein UL18 by means of two motifs present in the cytoplasmic tail.
J Immunol 180:969-79 2008.*Gli autori hanno contribuito in eguale misura al lavoro.

Ghiotto F, Fais F, Albesiano E, Sison C, Valetto A, Gaidano G, Reinhardt J, Kolitz JE, Rai K, Allen SL, Ferrarini M, Chiorazzi N. Similarities and differences beteween the light and heavy chain Ig variable region gene repertoires in chronic lymphocytic leukemia. Mol Med 12(11-12 ): 300-308, 2006.

Messmer BT, Albesiano E, Efremov DG, Ghiotto F, Allen SL, Kolitz J, Foa R, Damle RN, Fais F, Messmer D, Rai KR, Ferrarini M, Chiorazzi N. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med 200(4): 519-25, 2004.

Ghiotto F, Fais F, Valetto A, Albesiano E, Hashimoto S, Dono M, Ikematsu H, Allen SL, Kolitz J, Rai KR, Nardini M, Tramontano A, Ferrarini M, Chiorazzi N. Remarkably similar antigen receptors among a subset of patients with chronic lymphocytic leukemia. J Clin Invest 13(7): 1008-16, 2004.

Damle RN, Batliwalla FM, Ghiotto F, Valetto A, Albesiano E, Sison C, Allen SL, Kolitz J, Vinciguerra VP, Kudalkar P, Wasil T, Rai KR, Ferrarini M, Gregersen PK, Chiorazzi N. Telomere length and telomerase activity delineate distinctive replicative features of the B-CLL subgroups defined by immunoglobulin V gene mutations. Blood 103(2): 375-82, 2004.

Saverino D*, Ghiotto F*, Merlo A, Bruno S, Battini L, Occhino M, Maffei M, Tenca C, Pileri S, Baldi L, Fabbi M, Bachi A, De Santanna A, Grossi CE, Ciccone E. Specific recognition of the viral protein UL18 by CD85j/LIR-1/ILT2 on CD8+ T cells mediates the non-MHC-restricted lysis of human cytomegalovirus-infected cells. J Immunol 172(9):5629-37, 2004.*Gli autori hanno contribuito in eguale misura al lavoro.

Bruno S, Ghiotto F, Fais F, Fagioli M, Luzi L, Pelicci PG, Grossi CE, Ciccone E. PML gene is not involved in the regulation of MHC class I expression in human cell lines. Blood 101(9): 3514-9, 2003.

Damle RN, Ghiotto F, Valetto A, Albesiano E, Fais F, Yan XJ, Sison CP, Allen SL, Kolitz J, Schulman P, Vinciguerra VP, Budde P, Frey J, Rai KR, Ferrarini M, Chiorazzi N. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood 99(11): 4087-93, 2002.

Airoldi I, Guglielmino R, Ghiotto F, Corcione A, Facchetti P, Truini M, Pistoia V. Cytokine gene expression in neoplastic B cells from human mantle cell, follicular, and marginal zone lymphomas and in their postulated normal counterparts. Cancer Res 61(4):1285-90, 2001.

Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL, Buchbinder A, Budman D, Dittmar K, Kolitz J, Lichtman SM, Schulman P, Vinciguerra VP, Rai KR, Ferrarini M, Chiorazzi N. Ig V gene mutation status and CD38 expression as novel prognostic indicators in Chronic Lymphocytic Leukemia. Blood 94(6): 1840-1847,1999.

Fais F, Ghiotto F, Hashimoto S, Sellars B, Valetto A, Allen SL, Schulman P, Vinciguerra VP, Rai K, Rassenti LZ, Kipps TK, Dighiero G, Schroeder HW Jr, Ferrarini M, Chiorazzi N. Chronic Lymphocytic Leukemia B cells express restricted sets of mutated and unmutated antigen receptors. J Clin Invest 102(8): 1515-1525, 1998.

Fais F, Sellars B, Ghiotto F, Yan XJ, Dono M, Allen ST, Budman D, Dittmar K, Kolitz J, Lichtman SM, Schulman P, Schuster M, Vinciguerra VP, Rai K, Stevenson FK, Gregersen PK, Ferrarini M and Chiorazzi N. Examples of in vivo isotype switching in IgM
+ chronic lymphocytic leukemia B cells. J Clin Invest 98(7): 1659-1666, 1996.