Papers published by our lab

Metformin inhibits cell cycle progression of B-cell chronic lymphocytic leukemia cells.
Bruno S, Ledda B, Tenca C, Ravera S, Orengo AM, Mazzarello AN, Pesenti E, Casciaro S, Racchi O, Ghiotto F, Marini C, Sambuceti G, DeCensi A, Fais F.
Oncotarget 6(26):22624-40, 2015. PMID: 26265439


Igs expressed by chronic lymphocytic leukemia B cells show limited binding-site structure variability.
Marcatili P, Ghiotto F, Tenca C, Chailyan A, Mazzarello AN, Yan XJ, Colombo M, Albesiano E, Bagnara D, Cutrona G, Morabito F, Bruno S, Ferrarini M, Chiorazzi N, Tramontano A, Fais F.
J Immunol 190(11):5771-8, 2013. PMID: 23636053


N-(4-hydroxyphenyl)retinamide promotes apoptosis of resting and proliferating B-cell chronic lymphocytic leukemia cells and potentiates fludarabine and ABT-737 cytotoxicity.
Bruno S, Ghiotto F, Tenca C, Mazzarello AN, Bono M, Luzzi P, Casciaro S, Recchia A, Decensi A, Morabito F, Fais F.
Leukemia 26(10):2260-8, 2012. PMID: 22475870

A vector design that allows fast and convenient production of differently tagged proteins.
Scapolan O, Mazzarello AN, Bono M, Occhino M, Ogryzko V, Bestagno M, Scartezzini P, Bruno S, Fais F, Ghiotto F.
Mol Biotechnol 52(1):16-25, 2012. PMID: 22076571

Role of the B-cell receptor in chronic lymphocytic leukemia: where do we stand?
Fais F, Bruno S, Ghiotto F.
Ital J Anat Embryol 115(1-2):79-84, 2010. Review. PMID: 21072994

BH3-only proteins: the death-puppeteer's wires.
Ghiotto F, Fais F, Bruno S.
Cytometry A 77(1):11-21, 2010. Review. PMID: 19899133

Adoptive immunotherapy mediated by ex vivo expanded natural killer T cells against CD1d-expressing lymphoid neoplasms.
Bagnara D, Ibatici A, Corselli M, Sessarego N, Tenca C, De Santanna A, Mazzarello A, Daga A, Corvò R, De Rossi G, Frassoni F, Ciccone E, Fais F.
Haematologica 94(7):967-74, 2009. PMID: 19454494

Apoptosis of B-cell chronic lymphocytic leukemia cells induced by a novel BH3 peptidomimetic.
Ghiotto F, Fais F, Tenca C, Tomati V, Morabito F, Casciaro S, Mumot A, Zoppoli G, Ciccone E, Parodi S, Bruno S.
Cancer Biol Ther 8(3):263-71, 2009. PMID: 19164937



Papers in collaboration with other groups

Effects of miRNA-15 and miRNA-16 expression replacement in chronic lymphocytic leukemia: implication for therapy.
Cutrona G, Matis S, Colombo M, Massucco C, Baio G, Valdora F, Emionite L, Fabris S, Recchia AG, Gentile M, Neumaier CE, Reverberi D, Massara R, Boccardo S, Basso L, Salvi S, Rosa F, Cilli M, Zupo S, Truini M, Tassone P, Calabrese M, Negrini M, Neri A, Morabito F, Fais F, Ferrarini M.
Leukemia. 2017 Feb 3. doi: 10.1038/leu.2016.394. [Epub ahead of print] PMID: 28053325

A non-invasive approach to monitor chronic lymphocytic leukemia engraftment in a xenograft mouse model using ultra-small superparamagnetic iron oxide-magnetic resonance imaging (USPIO-MRI).
Valdora F, Cutrona G, Matis S, Morabito F, Massucco C, Emionite L, Boccardo S, Basso L, Recchia AG, Salvi S, Rosa F, Gentile M, Ravina M, Pace D, Castronovo A, Cilli M, Truini M, Calabrese M, Neri A, Neumaier CE, Fais F, Baio G, Ferrarini M.
Clin Immunol. 2016 Nov;172:52-60. doi: 10.1016/j.clim.2016.07.013. Epub 2016 Jul 16. PMID: 27430522

Discovery of a novel glucose metabolism in cancer: The role of endoplasmic reticulum beyond glycolysis and pentose phosphate shunt.
Marini C, Ravera S, Buschiazzo A, Bianchi G, Orengo AM, Bruno S, Bottoni G, Emionite L, Pastorino F, Monteverde E, Garaboldi L, Martella R, Salani B, Maggi D, Ponzoni M, Fais F, Raffaghello L, Sambuceti G.
Sci Rep. 2016 6:25092. PMID: 27121192

Prognostic Significance of VEGF after Twenty-Year Follow-up in a Randomized Trial of Fenretinide in Non-Muscle-Invasive Bladder Cancer.
Puntoni M, Petrera M, Campora S, Garrone E, Defferrari C, Torrisi R, Johansson H, Bruno S, Curotto A, DeCensi A.
Cancer Prev Res (Phila). 2016 9:437-44. PMID: 27045034

Neuroblastoma-targeted nanocarriers improve drug delivery and penetration, delay tumor growth and abrogate metastatic diffusion.
Cossu I, Bottoni G, Loi M, Emionite L, Bartolini A, Di Paolo D, Brignole C, Piaggio F, Perri P, Sacchi A, Curnis F, Gagliani MC, Bruno S, Marini C, Gori A, Longhi R, Murgia D, Sementa AR, Cilli M, Tacchetti C, Corti A, Sambuceti G, Marchiò S, Ponzoni M, Pastorino F.
Biomaterials. 2015 68:89-99. PMID: 26276694

Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin.
Caci E, Scudieri P, Di Carlo E, Morelli P, Bruno S, De Fino I, Bragonzi A, Gianotti A, Sondo E, Ferrera L, Palleschi A, Santambrogio L, Ravazzolo R, Galietta LJ.
PLoS One. 2015 10:e0131775. PMID: 26121472


Defective stromal remodeling and neutrophil extracellular traps in lymphoid tissues favor the transition from autoimmunity to lymphoma.
Sangaletti S, Tripodo C, Vitali C, Portararo P, Guarnotta C, Casalini P, Cappetti B, Miotti S, Pinciroli P, Fuligni F, Fais F, Piccaluga PP, Colombo MP.
Cancer Discov 4(1):110-29, 2014. PMID: 24189145


Dependence of immunoglobulin class switch recombination in B cells on vesicular release of ATP and CD73 ectonucleotidase activity.
Schena F, Volpi S, Faliti CE, Penco F, Santi S, Proietti M, Schenk U, Damonte G, Salis A, Bellotti M, Fais F, Tenca C, Gattorno M, Eibel H, Rizzi M, Warnatz K, Idzko M, Ayata CK, Rakhmanov M, Galli T, Martini A, Canossa M, Grassi F, Traggiai E.
Cell Rep Jun 3(6):1824-31, 2013. PMID: 23770243


Expression of Ig receptors with distinctive features indicating antigen selection by marginal zone B cells from human spleen.
Colombo M, Cutrona G, Reverberi D, Bruno S, Ghiotto F, Tenca C, Stamatopoulos K, Hadzidimitriou A, Ceccarelli J, Salvi S, Boccardo S, Calevo MG, De Santanna A, Truini M, Fais F, Ferrarini M.
Mol Med
19:294-302, 2013. PMID: 23877718

Association of TMEM16A cloride channel overexpression with airway goblet cell metaplasia.
Scudieri P, Caci E, Bruno S, Ferrera L, Schiavon M, Sondo E, Tomati V, Gianotti A, Zegarra-Moran O, Pedemonte N, Rea F, Ravazzolo R, Galietta LJ.
J Physiology 590 (Pt 23):6141-55, 2012. PMID: 22988141

A soluble form of CTLA-4 is present in paediatric patients with acute lymphoblastic leukaemia and correlates with CD1d+ expression.
Simone R, Tenca C, Fais F, Luciani M, De Rossi G, Pesce G, Bagnasco M, Saverino D.
PLoS One. 2012;7(9):e44654. doi: 10.1371/journal.pone.0044654. Epub 2012 Sep 25. PMID: 23049754


Neuroblastoma-targeted nanoparticles entrapping siRNA specifically knockdown ALK.
Di Paolo D, Brignole C, Pastorino F, Carosio R, Zorzoli A, Rossi M, Loi M, Pagnan G, Emionite L, Cilli M, Bruno S, Chiarle R, Allen TM, Ponzoni M, Perri P.
Mol Ther 19(6):1131-40, 2011. PMID: 21487394


Mutation pattern of paired immunoglobulin heavy and light variable domains in chronic lymphocytic leukemia B cells.
Ghiotto F, Marcatili P, Tenca C, Calevo MG, Yan XJ, Albesiano E, Bagnara D, Colombo M, Cutrona G, Chu CC, Morabito F, Bruno S, Ferrarini M, Tramontano A, Fais F, Chiorazzi N.
Mol Med 17(11-12):1188-95, 2011. PMID: 21785810


Intraclonal cell expansion and selection driven by B cell receptor in chronic lymphocytic leukemia.
Colombo M, Cutrona G, Reverberi D, Fabris S, Neri A, Fabbi M, Quintana G, Quarta G, Ghiotto F, Fais F, Ferrarini M.
Mol Med 17(7-8):834-9, 2011. PMID: 21541442

High frequency of development of B cell lymphoproliferation and diffuse large B cell lymphoma in Dbl knock-in mice.
Ognibene M, Barbieri O, Vanni C, Mastracci L, Astigiano S, Emionite L, Salani B, Fedele M, Resaz R, Tenca C, Fais F, Sabatini F, De Santanna A, Altruda F, Varesio L, Hirsch E, Eva A.
J Mol Med (Berl) 89(5):493-504, 2011. PMID: 21221514

The recruitment of two consecutive and different waves of host stem/progenitor cells during the development of tissue-engineered bone in a murine model.
Tasso R, Fais F, Reverberi D, Tortelli F, Cancedda R.
Biomaterials 31(8):2121-9, 2010. PMID: 20004968


CX3CR1 is expressed by human B lymphocytes and mediates [corrected] CX3CL1 driven chemotaxis of tonsil centrocytes.
Corcione A, Ferretti E, Bertolotto M, Fais F, Raffaghello L, Gregorio A, Tenca C, Ottonello L, Gambini C, Furtado G, Lira S, Pistoia V.
PLoS One 4(12):e8485, 2009. Erratum in: PLoS One. 2010;5(1). PMID: 20041188

Recruitment of a host's osteoprogenitor cells using exogenous mesenchymal stem cells seeded on porous ceramic.
Tasso R, Augello A, Boccardo S, Salvi S, Caridà M, Postiglione F, Fais F, Truini M, Cancedda R, Pennesi G.
Tissue Eng Part A 15(8):2203-12, 2009. PMID: 19265473


Development of sarcomas in mice implanted with mesenchymal stem cells seeded onto bioscaffolds.
Tasso R, Augello A, Carida' M, Postiglione F, Tibiletti MG, Bernasconi B, Astigiano S, Fais F, Truini M, Cancedda R, Pennesi G.
Carcinogenesis 30(1):150-7, 2009. PMID: 18849298